Authorities across the region have taken draconian measures to curb the disease, closing airports and halting passenger flights, and bringing major hubs like Dubai and Abu Dhabi to a standstill.
The Arab Air Carriers' Organization (AACO) and the International Air Transport Association (IATA) have appealed for urgent financial aid from governments, warning that inaction will imperil the industry's future.
"The airline industry faces its gravest crisis.... For airlines, it's apocalypse now," IATA chief Alexandre de Juniac said this week.
International airlines have in the past bitterly criticized Middle East carriers for receiving official support from governments flush with oil revenue, claiming that it undermines free competition.
With the oil price plummeting, London-based Capital Economics tipped the region's economy to contract by 1.7% this year, the worst in almost 4 decades – limiting governments' ability to continue funding national airlines.
The AACO, which represents some 30 Arab public and private carriers, has called for support packages including tax relief, waivers of a string of fees and charges, and help with new virus-related costs.
"AACO sees the above measures as very important for governments to adopt in order to avoid a scenario where airlines would not be able to provide the public with convenient services," it said in a statement.
It warned that without action, the post-coronavirus era will see a thinner lineup of carriers that will deprive regional passengers of the choice they enjoyed in the past.
IATA, which represents 290 airlines worldwide, said that 2020 revenues of Middle Eastern carriers, which operate over 1,300 aircraft, are expected to drop by $19 billion, a 39% decline over last year.
The impact on the region's air transport sector imperils at least 800,000 jobs and could result in the loss of tens of millions of passengers this year, it warned.
Qatar Airways, the second largest in the region, is among a few carriers that are still operating through the crisis, though at just 40% of its schedule.
"We have adjusted operations. There is still demand regarding the repatriation business," its chief strategy and transformation officer Thierry Antinori told Agence France-Presse (AFP), describing its services as the "last lifeline" for many.
He declined to comment on the prospect of staff layoffs, but said employees have been offered unpaid leave.
Other airlines have resorted to deep cost-cutting measures without delay, and cuts to the region's $100 billion worth of aircraft orders may be on the cards.
"If government support is not provided, carriers may be forced to cancel orders," Muhammad AlBakri, IATA vice president for Africa and the Middle East, told AFP.
Dubai's Emirates Airline, the largest carrier in the region and one of the world's biggest, slashed staff salaries by between 25% and 50% for 3 months, saying the measure was designed to avoid layoffs.
Emirates is among a few regional airlines which have been posting profits, but those profits have moderated in recent years amid an economic slowdown.
Many of the 19 state-owned Arab carriers have been posting losses, forcing governments to plug the gap.
Etihad Airways, based in the United Arab Emirates capital Abu Dhabi, has suffered $5.5 billion in losses in the past 4 years and was already undergoing restructuring.
Its chief executive Tony Douglas posted a video this week offering assurance that "afterwards when we all want to get back to our normal lives, we want to travel, Etihad will still be there."
But Qatar Airways chief executive officer Akbar al-Baker said many airlines will go bust as demand for travel is ravaged, and that the future of the industry will depend on which airlines take "very clever, very prudent decisions."
"People that were bragging about not taking state aid and being independent are now themselves all over the world asking for state aid," he told Bloomberg Television, predicting many airlines will go "belly up."
"In this very difficult period, it will only be the survival of the fittest." – Rappler.com