Merck & Co said on Friday, November 26, updated data from the study of its experimental COVID-19 pill showed lower efficacy in reducing the risk of hospitalization and deaths than an earlier interim analysis, cutting them by 30% in the study.
The drugmaker released interim data in October showing a roughly 50% reduction in hospitalizations and deaths in 775 patients. The updated rate on Friday is based on data from over 1,400 patients.
Merck’s shares fell 3% to $79.41 in premarket trading, amid a fall in the broader markets.
The company said the data on the drug molnupiravir, developed with Ridgeback Biotherapeutics, had been submitted to the US Food and Drug Administration ahead of a meeting of its expert advisers on Tuesday, November 30.
A planned interim analysis of the data last month showed that 7.3% of those given molnupiravir twice a day for five days were hospitalized and none had died by 29 days after the treatment. That compared with a hospitalization rate of 14.1% for placebo patients.
In the updated data, 6.8% of those given molnupiravir were hospitalized and one person died, while the other placebo group had a hospitalization rate of 9.7%. – Rappler.com