He will address French soldiers stationed in the city of Gao in Mali's deeply troubled north. The French base there has 1,600 soldiers – the biggest outside the country.
The troops are part of Operation Barkhane, a French counterterror operation whose mission is to target jihadist groups operating in the Sahel region south of the Sahara Desert.
Set up in 2014, the operation comprises around 4,000 soldiers who are deployed across 5 countries – Mauritania, Mali, Niger, Chad and Burkina Faso. It operates Mirage 2000 fighter jets and drones for gathering intelligence.
Macron will be accompanied by Foreign Minister Jean-Yves Le Drian and Minister of Armed Services Sylvie Goulard, as well as the head of the French development agency (AFD) Remy Rioux.
Macron will hold talks with Malian counterpart Ibrahim Boubacar Keita on the fight against terrorism and the west African country's rocky path to normality since a 2015 peace deal.
Northern Mali fell to jihadist groups linked to Al-Qaeda in March 2012, and these forces were driven out of key towns by a French-led military intervention the following year.
But jihadists continue to roam the country's north and center, mounting attacks on civilians and the army, as well as French and UN forces still stationed there.
Germany is the biggest contributor to the UN force in Mali, or MINUSMA, which has been stationed there since July 2013 and has just over 12,000 military and police personnel on what is considered the UN's most dangerous active peacekeeping deployment.
Sources in his entourage said 39-year-old Macron would seek to emphasize the need for closer European cooperation in the fight against jihadists, especially with EU heavyweight Germany.
France wants a "new Franco-German impetus so that Europe plays a greater role in defense and security matters, especially in Africa and the Sahel," a source said.